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Germs in the Family: The Long-Term Consequences of Intra-Household Endemic Respiratory Disease Spread

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Yves here. I’m normally leery of economists attempting to model non-economic questions, but this looks to be a well-defined study examining the effects of childhood respiratory infections. And mind you, the diseases in question are “just” respiratory ailments, as in they do not afflict other organs the way Covid does. The conclusions are worrying in and of themselves as well as in terms of their implications for Covid, given that Omicron in particular is producing a much higher level of serious cases, including hospitalization, among children up to nine years old, than earlier variants. This study found infants were two to three times as likely to be hospitalized as older children, and that their hospitalization damaged their educational and job prospects without producing greater

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Yves here. I’m normally leery of economists attempting to model non-economic questions, but this looks to be a well-defined study examining the effects of childhood respiratory infections. And mind you, the diseases in question are “just” respiratory ailments, as in they do not afflict other organs the way Covid does.

The conclusions are worrying in and of themselves as well as in terms of their implications for Covid, given that Omicron in particular is producing a much higher level of serious cases, including hospitalization, among children up to nine years old, than earlier variants. This study found infants were two to three times as likely to be hospitalized as older children, and that their hospitalization damaged their educational and job prospects without producing greater resistance to later childhood respiratory infection.

By N. Meltem Daysal, Associate Professor of Economics, University of Copenhagen, Hui Ding, PhD student in Economics, Stanford University, Maya Rossin-Slater, Associate Professor of Health Policy, Stanford University School of Medicine and Hannes Schwandt, Assistant Professor, Northwestern University, School of Education and Social Policy (SESP). Originally published at VoxEU

Pandemics have a major impact on households and the economy. But how common endemic viruses affect long-term population human capital and economic outcomes is not well understood. This column uses data from Denmark to explore the mechanisms and consequences of a child’s exposure to respiratory disease in early life. Younger siblings have two to three-times higher rates of hospitalisation for respiratory conditions during their first year of life compared to older siblings. The family unit plays a central role in virus transmission and birth order can influence children’s longer-term outcomes.

The COVID-19 pandemic has reignited interest in understanding the societal costs of infectious diseases, which are often measured in terms of their direct and immediate impact on public health and economic activity (Adda 2016). While a large body of research focuses on the effects of pandemics on households and the economy (e.g. Janke et al. 2020, Moroni et al. 2020, Alon et al. 2020, Conti 2020, Baldwin 2020), the parallel question of how common endemic viruses impact society remains less understood. In addition, even less attention is paid to the potential long-term consequences of these viruses on population human capital and economic outcomes.

Respiratory Disease: The Role of Birth Order and the Long-Run Impacts

In our paper (Daysal et al. 2021), we use Danish population-level administrative data on 35 birth cohorts to comprehensively analyse both the mechanisms through which infants become infected by respiratory viruses as well as the consequences of early-life respiratory disease exposure for their later outcomes.

We begin by documenting a striking disparity in the likelihood of severe respiratory disease in early childhood by birth order. Using data on all first- and second-born siblings born in Denmark between 1980 and 2015, we find that younger siblings have two-to-three-times higher rates of hospitalisation for respiratory conditions during their first year of life compared to the older siblings at the same age. This gap is particularly large when hospitalisations are measured in the first three months of life.

The hospitalisation disparity is larger if the younger sibling is born in the autumn or winter, when respiratory viruses circulate more frequently. The gap is also larger for siblings with shorter birth spacing, who may be more prone to close contact that facilitates virus transmission.

These patterns highlight the centrality of the family unit in virus transmission and the hitherto under-studied mechanism by which birth order might influence children’s longer-term outcomes: older children ‘bring home’ common viruses (e.g. from group childcare environments), putting their younger siblings at heightened risk of severe respiratory illness in the first few months of life.

Causal Long-Term Effects

To identify the long-term causal impacts of early-life respiratory disease exposure, we combine the birth order variation in the likelihood of severe respiratory infection with variation in local disease prevalence. Local respiratory disease prevalence among children is largely driven by highly infectious conditions, such as the respiratory syncytial virus, or RSV, which spread across locations in irregular waves (Pitzer et al. 2015).

We construct a municipality-level index to capture respiratory disease exposure during each child’s first year of life from slightly older children in the community. Specifically, we calculate the number of hospitalisations for respiratory conditions per 100 children aged 13 to 71 months in each municipality (excluding siblings), and then assign to each child the cumulative child hospitalisation rate in their municipality over their first 12 months of life. We then use our sample of siblings to estimate the differential effect of the respiratory disease index for younger compared to older siblings.

Our regression models control for time-invariant differences across municipalities that might drive differences in disease exposure and aggregate and seasonal trends in respiratory illness, as well as a large set of observable individual and family characteristics.

We show that the local respiratory disease index strongly predicts the likelihood that a child is hospitalised for a respiratory illness during the first year of life. This impact is much larger for younger relative to older siblings. Moving from the 25th to the 75th percentile in the disease index distribution is associated with a 0.021 differential increase in the number of respiratory illness hospitalisations in the first year of life for younger relative to older children, representing an additional 30.9 % increase at the sample mean. This effect is in part driven by a differential increase in hospitalisations for RSV, which is a mild illness in most older children but can be serious among infants.

In the long run, the increased exposure to severe respiratory illness during infancy among second-born children translates into worse educational and labour market outcomes for them. We find that, for the younger siblings, moving from the 25th to the 75th percentile in the disease index distribution is associated with a 0.4 percentage point (0.5%) differential decline in the likelihood of high school graduation and a 1.3% additional reduction in earnings at age 30.

We also examine the impact of respiratory illness exposure in the first year of life on hospitalisations for respiratory conditions in later childhood. We find that higher respiratory disease exposure before age one is associated with a lower likelihood of hospitalisation for all respiratory conditions at ages three to four, consistent with the hypothesis of immunity formation.

We do not, however, observe a protective effect of first-year-of-life RSV exposure on the likelihood of RSV hospitalisation during later childhood. This result is consistent with RSV not being an immunising disease – that is, an RSV infection does not provide immunity against future illness. This lack of immunity formation, combined with the fact that RSV accounts for a large share of all respiratory hospitalisations during infancy (30% among second-born children), suggests that RSV might play a particularly important role in driving adverse long-term impacts on educational and economic outcomes.

Filling an Important Gap in the Existing Literature

Ample empirical evidence links adverse conditions, including health shocks, during early childhood to worse socioeconomic outcomes in the long run (Barker 1990, Currie 2008, Almond and Currie 2011, Almond et al. 2018). Consistent with this extensive literature, the current research on the effects of infectious viruses indicates long-lasting negative effects on health and economic outcomes.

However, these studies are primarily based on severe infectious diseases, such as malaria and polio (e.g. Bleakley 2010, Barreca 2010, Venkataramani 2012, Gensowski 2019, Fink et al. 2021), or on pandemic influenza outbreaks, including the 1918 Spanish Flu and the 1957 Asian Flu (e.g. Almond 2006, Almond and Mazumder 2005, Lin and Liu 2014, Kelly 2011). Severe infectious diseases like malaria and polio continue to plague the developing world but they have been largely eradicated in high-income countries.

Moreover, the evidence from pandemics may not apply to understanding the long-term impacts of endemic viruses to which individuals may be exposed many times during their lives. Studies from evolutionary biology highlight the importance of physiological adaptation (Bateson et al. 2014, Gluckman and Hanson 2006) and identify a high rate of immune-system learning in the first year of life (Holt and Jones 2000, M’Rabet et al. 2008, Cote et al. 2010). Thus, exposure to an infectious disease in infancy may increase immunity for an individual if they are exposed to the same virus at older ages, suggesting a potentially non-linear relationship between early-life exposure and long-term outcomes (Fink et al. 2021).

Emerging evidence on the long-term impacts of endemic influenza, on the other hand, has focused on the in utero period (Schwandt 2018). Our study contributes to this literature on endemic disease by focusing on the first year of life and analysing transmission mechanisms.

COVID-19 and the Road Ahead

Currently, the COVID-19 pandemic continues with no clear end in sight. While children have largely not been considered to be a high-risk group in terms of infection with the SARS-CoV-2 virus (Schwandt 2020), the pandemic may have lasting and dynamic impacts on children through its effects on other infectious diseases.

Policies implemented during the pandemic – including travel restrictions and school closures – have reduced the spread of other respiratory viruses, including RSV (Leung et al. 2020, Cowling et al, 2020). Epidemiological models predict that pandemic periods with muted spread of common infectious diseases are followed by stronger outbreaks (Baker et al. 2020).

Since the risk of severe cases of childhood disease is particularly high during the first year of life, the pandemic might have the severest long-term impact on infants who are born at the end of the pandemic and who are then exposed to stronger childhood disease outbreaks when the pandemic is over.

Overall, our study highlights the importance of the family unit in disease transmission during infancy and offers novel information that can inform cost-benefit evaluations of policies designed to curb the transmission of endemic viruses, including vaccination mandates, drug distribution programmes, and sick pay regulations (Bhalotra and Venkataramani 2015, White 2019, Pichler and Ziebarth 2020, Bütikofer and Salvanes 2020, Marie and Castello 2020).

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